The Potential Anti-Osteosarcoma Activity from Naturally Extracted Phenolic Compound: A Scoping Review

Chemotherapy is the standard treatment component for osteosarcoma alongside surgery. Nevertheless, survival rate of patients diagnosed with has not changed over past three decades. Phenolic compounds are widely reported having anti-proliferative effects against various cancers including osteosarcoma. Based on framework published by Arskey and O’Malley [1] this scoping review was conducted to map literature anti-osteosarcoma activity phenolic compounds.
 
 Initially, a search from electronic databases like PubMed, Scopus, EBSCO, Google Scholar Science Direct, Web Science. Articles activities that were between January 2001 May 2022 retrieved. The process guided systematic reviews meta-analysis (PRISMA) [2]. In total, 3168 articles retrieved search. After thorough screening, 95 included in final analysis after met inclusion criteria. Most studies year 2011 (84.2%) only few 2010 (15.8%) (Table 1). Among selected studies, 53 types identified have promising activity. Curcumin (12.6%) most compound followed quercetin (11.6%) resveratrol (10.5%) 2). All utilised in-vitro (n = 95), some also in-vivo evaluations 17). MG-63 (50.5%) be used cell line. Meanwhile, BALB/c nude mice (58.8%) frequently evaluation. review, it found 13 analysed combination chemotherapeutic drugs 53.8% demonstrating synergistic effect.
 number increased dramatically 10 years. became main choice oncotherapy research as represents major secondary metabolite plant. all several evaluations. For study, because line phenotypic stability [3]. mostly utilization immunocompromised become an essential tool drug evaluation cancer maintain tumour pathological traits [4]. Even though showed remarkable inhibitory effect in-vivo, no clinical trial study reported. Combination one efforts induce effectiveness treatment. Seven when combined drug. desired drug-drug interaction application can efficacy [5]. conclusion, indicated significant increase compounds. Yet, gaps remaining investigated further continuation so development compound-based realised soon.